It becomes a plot point later on, providing a means to access the BFG. A scientist in the opening gets her arm lopped off by a closing door.Always Chaotic Evil: The monsters are driven to kill, unable to be reasoned with.It turns out that she's mutating into a demon. They both ogle her for a few seconds, but then the Kid gets embarrassed and steps in to try and help her, and Portman gives him a dirty look for spoiling it.
It seems that like many members of the crew she has been driven insane from whatever horrors she has witnessed.
However, the demons in the film do seem somewhat smarter than their game counterparts, one Imp is even intelligent enough to run away when shot at and set up an ambush later down the line.
Doom 3 also has a scientist note that the demons have bullet-resistant skin (it takes a good 15-20 bullets to put down a basic Imp), which doesn't seem to be the case in the film.